Jan Tuckermann

Ulm University

Dr. Jan Tuckermann received his PhD from Karlsruhe University, Germany, in 1999, and conducted postdoctoral research at the German Cancer Research Center in Heidelberg until 2003. He then served as Group Leader at the Leibniz Institute for Age Research – Fritz Lipmann Institute in Jena, Germany, until 2012, when he was appointed Full Professor and Director of the Institute of Comparative Molecular Endocrinology at the University of Ulm.

His research focuses on cell type-specific molecular mechanisms of steroid receptors at the intersection of bone biology, immunology, and metabolism. Utilizing transgenic mouse models and functional genomics, his work provides insights into the roles of steroid hormones in health and disease.

Dr. Tuckermann has published more than 180 peer-reviewed articles in high-impact journals including Nature, Nature Communications, Cell Metabolism, Annals of the Rheumatic Diseases, and Nature Immunology. He holds an H-index of over 60.

He currently serves as President of the German Society of Endocrinology (2023–2026).

10 Most important Publications: 5. Selected Publications 1. Auger, J.-P., Zimmermann, M., Faas, M., Stifel, U., Chambers, D., Krishnacoumar, B., Taudte, V., Grund, C., Erdmann, G., Scholtysek, C., Uderhardt, S., Ben Grahim, O, Maté, M. P., Stoll, C., Böttcher, M., Palumbo-Zerr, K., Mangen, M.S.J., Dzamukova, M., Kieler, M., Hofmann, M., Blüml, S., Schabbauer, G., Mougiakakos, D., Sonnewald, U., Hartmann, F., Simon, D., Kleyer, A., Grüneboom, A., Finotto, S., Latz, E., Hofmann, J., Schett, G., Tuckermann, J., Krönke G., (2024). TCA cycle rewiring promotes anti-inflammatory effects of glucocorticoids. Nature 629, 184. doi: 10.1038/s41586-024-07282-7 2. Caratti, G., Stifel, U., Caratti, B., Jamil, A.J.M., Chung, K.J., Kiehntopf, M., Graler, M.H., Bluher, M., Rauch, A., and Tuckermann, J.P. (2023). Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance. Nat Commun 14, 2271. doi: 10.1038/s41467-023-37831-z 3. Caratti G*, Desgeorges T*, Juban G, Stiffel U, Fessard A, Koenen M, Caratti B, Théret M, Skurk C, Chazaud B#, Tuckermann JP#, Mounier R#. (2023) Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids. EMBO Rep. 24(2):e55363. doi: 10.15252/embr.202255363. # equal correspondence. 4. Ahmad M, Krüger BT, Kroll T, Vettorazzi S, Dorn AK, Mengele F, Lee S, Nandi S, Yilmaz D, Stolz M, Tangudu NK, Vázquez DC, Pachmayr J, Cirstea IC, Spasic MV, Ploubidou A, Ignatius A, Tuckermann J. (2022) Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing. Bone Res. 10(1):33. doi: 10.1038/s41413-022-00195-z. 5. Caratti B, Fidan M, Caratti G, Breitenecker K, Engler M, Kazemitash N, Traut R, Wittig R, Casanova E, Ahmadian MR, Tuckermann JP#, Moll HP#, Cirstea IC#. (2022) The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth. Sci Signal. 15(726):eabm4452. doi: 10.1126/scisignal.abm4452. # equal correspondence 6. Loft A, Schmidt SF#, Caratti G, Stifel U, Havelund J, Sekar R, Kwon Y, Sulaj A, Chow KK, Alfaro AJ, Schwarzmayr T, Rittig N, Svart M, Tsokanos FF, Maida A, Blutke A, Feuchtinger A, Møller N, Blüher M, Nawroth P, Szendrödi J, Færgeman NJ, Zeigerer A, Tuckermann J#, Herzig S#. (2022) A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis. Cell Metab. 34(3):473-486.e9. doi: 10.1016/j.cmet.2022.01.004. # equal correspondence 7. Najafova Z, Liu P, Wegwitz F, Ahmad M, Tamon L, Kosinsky RL, Xie W, Johnsen SA#, Tuckermann J#. (2021) RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk. Cell Death Differ. 28(2):700-714. doi: 10.1038/s41418-020-00614-w. # equal correspondence 8. Koenen M, Culemann S, Vettorazzi S, Caratti G, Frappart L, Baum W, Krönke G, Baschant U#, Tuckermann JP#. (2018) Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis. Ann Rheum Dis. 77(11):1610-1618. doi: 10.1136/annrheumdis-2017-212762. # equal correspondence 9. Liu P, Lee S, Knoll J, Rauch A, Ostermay S, Luther J, Malkusch N, Lerner UH, Zaiss MM, Neven M, Rauner M, David J-P, Bertolino P, Zhang CX, Tuckermann JP. (2017) Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis. Cell Death Diff. 24(4):672-682. doi: 10.1038/cdd.2016.165. 10. Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klaßen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David JP, Gräler M, Kleiman A, Tuckermann JP. (2015) Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nat Commun. 6:7796. doi: 10.1038/ncomms8796. 11. Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss MM, Angel PE, Lerner UH, David JP, Reichardt HM, Amling M, Schütz G, Tuckermann JP. (2010) Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 11(6):517-31. doi: 10.1016/j.cmet.2010.05.005. Complete list of publications: https://pubmed.ncbi.nlm.nih.gov/?term=Tuckermann+J&sort=date&size=100