New and Innovative Treatments

Concurrent Session 8

Date: Saturday, April 26, 2025
Time: 8:45 AM to 10:15 AM

Description

Moderators

Ji Hyeon Ju 

Magali Cucchiarini 
8:45 AM - 9:25 AM

Role of Neural Crest Derived Cells (NCC) in Limb Regeneration of Regenerative Model Species 

Farida Djouad
9:25 AM - 9:35 AM

077: APOPTOTIC BODY-INSPIRED NANOTHERAPEUTICS TARGET BRD4-REGULATED SYNOVIAL MACROPHAGE TO ATTENUATE OSTEOARTHRITIS

Huan-Tian Zhang
9:35 AM - 9:45 AM

078: SELECTION OF AN APTAMER EXHIBITING HIGH AFFINITY FOR HEALTHY VERSUS OSTEOARTHRITIC HUMAN CHONDROCYTES

Huaizhi Chen
9:45 AM - 9:55 AM

079: DECELLULARIZED CARTILAGE EXTRACELLULAR MATRIX AS MULTIFACETED VISCOSUPPLEMENT FOR OSTEOARTHRITIS.

Eun Je Jeon
9:55 AM - 10:05 AM

080: COLLAGEN TARGETING NANOMICELLE WITH HIGH PENETRATION AND RETENTION IN CARTILAGE FOR IMPROVED TREATMENT OF OSTEOARTHRITIS

Saptomee Chakraborty
10:05 AM - 10:07 AM

081: MAGNETIC NANOEMULSIONS AS INTRAARTICULAR THERAPEUTIC STRATEGY FOR OSTEOARTHRITIS: IN VITRO AND IN VIVO FINDINGS

Luminita Labusca
10:07 AM - 10:09 AM

082: TARGETING NLRP3/NLRP1 INFLAMMASOMES: PRECLINICAL EFFICACY AND SAFETY OF INV-1498 FOR OSTEOARTHRITIS

Yurim Lee
10:09 AM - 10:11 AM

083: INTERLEUKIN 11 AS A NOVEL TARGET FOR ARTHROFIBROSIS THERAPY

Miguel Angel De Jesus
10:11 AM - 10:13 AM

084: ADENOSINE AND GUANOSINE-BASED OLIGONUCLEOTIDE ATTENUATES CATABOLIC PHENOTYPES IN CHONDROCYTES AND SLOWS PROGRESSION OF SURGICALLY INDUCED OSTEOARTHRITIS

Yoonhee Kim
10:13 AM - 10:15 AM Q & A

  • Role of Neural Crest Derived Cells (NCC) in Limb Regeneration of Regenerative Model Species

    Description

    Articular cartilage is susceptible to various traumatic or age-related injuries. Given the tissue limited regenerative ability, such injuries, which result in the permanent destruction of the extracellular matrix, represent one of the most challenging issues in musculoskeletal medicine. Regenerative medicine for articular cartilage using mesenchymal stromal/stem cells (MSC) has demonstrated promising results in addressing traumatic or age-related changes that could result in osteoarthritis. However, MSCs have not proven sufficiently effective for long-term joint tissue regeneration, highlighting the need to find a new source of cells to regenerate cartilage.
    Neural crest derived cells (NCC) are involved in most, if not all, spontaneous regenerative processes in regenerative species. During caudal fin regeneration in zebrafish we showed the presence and the role of NCC in the regenerating tissue, and reveal the critical function of the NRG1/ErbB pathway in controlling the dialogue between macrophages and NCC. More recently, we have described the central role of NCC-derived chondrocytes in the cartilage regeneration process in zebrafish. We are currently addressing the role of NCC on mammalian limb regeneration using the mouse embryo model at E10.5. 
    During the conference, I will present our recent data on the role of NCC during limb regeneration of mouse embryo.

    Speakers
    Farida Djouad