Molecular Drivers of OA
Concurrent Session 10
Time: 2:00 PM to 3:30 PM
Description
| Moderators |
Cindy Boer Raghunatha Yammani |
| 2:00 PM - 2:40 PM |
Osteoarthritis: Pain, Anxiety, Memory Deficits, and Neurochemical Changes Katarzyna Starowicz |
| 2:40 PM - 2:50 PM |
101: PRDM16 MAINTAINS CARTILAGE HOMEOSTASIS BY MODULATING CHONDROCYTE PHENOTYPES Eloise Fadial |
| 2:50 PM - 3:00 PM |
102: TRANSCRIPTOME REGULATION ANALYSIS IN OSTEOARTHRITIS PRIMARY TISSUES IDENTIFIES HIGH-CONFIDENCE EFFECTOR GENES Georgia Katsoula |
| 3:00 PM - 3:10 PM |
103: TARGETING YAP1-REGULATED GLYCOLYSIS IN FIBROBLAST-LIKE SYNOVIOCYTES IMPAIRS MACROPHAGE INFILTRATION TO AMELIORATE DIABETIC OSTEOARTHRITIS PROGRESSION Zhen-Yan Li |
| 3:10 PM - 3:20 PM |
104: ROLE OF ACETYLCHOLINESTERASE IN CARTILAGE HOMEOSTASIS AND OSTEOARTHRITIS DEVELOPMENT Jun Liu |
| 3:20 PM - 3:22 PM |
105: MITOCHONDRIAL DYSFUNCTION AND INTERFERON SIGNALING IN OSTEOARTHRITIS PROGRESSION: ROLE OF CYTIDINE/URIDINE MONOPHOSPHATE KINASE 2 (CMPK2)Â Abhilekha Pilania |
| 3:22 PM - 3:24 PM |
106: EXPLORATION OF THE MECHANISM UNDERLYING ANGIOGENESIS IN SYNOVIUM OF OA KNEE JOINTS Hirotaka Tsuno |
| 3:24 PM - 3:26 PM |
107: SENESCENT IMMUNE CELLS DRIVE AGE-RELATED OSTEOARTHRITIS VIA GCA-PLXINB2 AXIS Changjun Li |
| 3:26 PM - 3:28 PM |
108: ELEVATED EXPRESSION OF PIEZO1 ACTIVATES THE CGAS-STING PATHWAY IN CHONDROCYTES BY RELEASING MITOCHONDRIAL DNA Zhifeng Yu |
| 3:28 PM - 3:30 PM | Q & A |
Osteoarthritis: Pain, Anxiety, Memory Deficits, and Neurochemical Changes
DescriptionThis session will delve into the intricate relationship between chronic pain, mood disorders, and neurochemical alterations in osteoarthritis (OA). Participants will explore how OA-induced chronic pain impacts behavior and brain function in rat models, including alterations in memory, depressive-like behavior, and neurotransmitter levels. The potential of the endocannabinoid system, specifically through pharmacological manipulation—in mitigating these effects will be discussed. Additionally, the session will cover how network analysis can reveal critical neurochemical changes in brain structures like the nucleus accumbens, highlighting its role in the affective processing of chronic pain. This comprehensive overview will enhance understanding of the mechanisms underlying chronic pain and identify potential therapeutic targets for better management of OA-related pain and associated mood disorders.
Speakers