Beyond Hip & Knee OA
Concurrent Session 9
Time: 2:00 PM to 3:30 PM
Description
| Moderators |
Thomas Link Garrett Bullock |
| 2:00 PM - 2:40 PM |
Mechanosensing and Plasticity of Tendons and Ligaments Hiroshi Asahara |
| 2:40 PM - 2:50 PM |
093: ZOLEDRONATE SUPPRESSES OSTEOCLASTS IN THE SUBCHONDRAL BONE AND M1 MACROPHAGES IN THE SYNOVIUM TO ALLEVIATE OSTEOARTHRITIC CHANGES IN A RAT MODEL OF ROTATOR CUFF TEAR ARTHROPATHY Hiroki Tawaratsumida |
| 2:50 PM - 3:00 PM |
094: TRABECULAR BONE TEXTURE IS ASSOCIATED WITH PROGRESSION TO EROSIVE OSTEOARTHRITIS IN FINGER JOINTS: THE LONGITUDINAL NOR-HAND COHORT Marcin Wolski |
| 3:00 PM - 3:10 PM |
095: DOES PREOPERATIVE DIAGNOSIS MAKE A DIFFERENCE IN PATIENTS AGED 65 AND OLDER? A COMPARATIVE ANALYSIS OF GLENOHUMERAL OSTEOARTHRITIS VERSUS ROTATOR CUFF ARTHROPATHY CLINICAL OUTCOMES FOLLOWING REVERSE SHOULDER ARTHROPLASTY Kevin Gunawardana |
| 3:10 PM - 3:20 PM |
096: ANKLE ALIGNMENT ALTERATIONS FOLLOWING HIGH TIBIAL OSTEOTOMY MAEASURED BY STEREOS WHOLE-LEG RADIOGRAPHY Yuichiro Machiyama |
| 3:20 PM - 3:22 PM |
097: RELATION OF DIFFERENT TYPES OF ANTIDEPRESSANTS USE TO PAIN SEVERITY AND MEASURES OF PAIN SENSITIZATION IN KNEE OSTEOARTHRITIS Zhiqiang Wang |
| 3:22 PM - 3:24 PM |
098: WALKING WITH THE LOW BACK PAIN PATIENT: A PATIENT JOURNEY APPROACH TO UNDERSTANDING CURRENT LOW BACK PAIN MANAGEMENT Alessandra Cory Marcelo |
| 3:24 PM - 3:26 PM |
099: CLINICAL OUTCOMES OF A NEW FOOT-WORN NON-INVASIVE BIOMECHANICAL INTERVENTION COMPARED TO TRADITIONAL PHYSICAL THERAPY IN PATIENTS WITH CHRONIC LOW BACK PAIN. A RANDOMIZED CLINICAL TRIAL Ganit Segal |
| 3:26 PM - 3:28 PM |
100: ROLE OF LUBRICIN IN TEMPOROMANDIBULAR JOINT HOMEOSTASIS Soichiro Negishi |
| 3:28 PM - 3:30 PM | Q & A |
Mechanosensing and Plasticity of Tendons and Ligaments
DescriptionMuscles transmit energy to joints via tendons, and as proposed in Hill's model (1922 Nobel Prize winner), tendons play a crucial role in controlling and amplifying movement functions due to their viscoelastic properties. However, despite the clear active function of tendons in the jumping ability of kangaroos, the complete mechanism has not been fully elucidated even after 100 years. PIEZO1 E756del, the gain-of-function (GOF) polymorphism of the mechanoreceptor Piezo1 is found in 30% of people in West Africa, Jamaica, and African Americans, providing malaria resistance. Interestingly, this distribution closely matches the distribution of the top 100 records in the 100-meter race. Therefore, in collaboration with the Athrome Consortium, an international athlete genomics organization, we investigated the frequency of the active PIEZO1 E756del in top sprinters and the general population in Jamaica. The results showed that Jamaican sprinters had a significantly higher ratio of functional polymorphisms compared to the general population.
Based on these findings, we created mice with a gene mimicking this Piezo1GOF throughout their bodies. Astonishingly, these global Piezo1GOF mice demonstrated about 1.7 times the jumping ability of wild-type mice. Furthermore, we created tendon-specific and muscle-specific Piezo1GOF mice. While the muscle-specific Piezo1GOF mice exhibited the same level of motor function as wild-type mice, the tendon-specific Piezo1GOF mice displayed remarkable jumping ability and maximum speed similar to the global Piezo1GOF mice. This phenotype was found to be induced by the upregulation of Mkx, which we first identified as a master transcription factor organizing the development and homeostasis of tendon.
These discoveries reveal the new fact that tendons have the potential to dramatically enhance muscle and motor functions. They also indicate that genetic polymorphisms can significantly influence individual athletic performance. Further research will deepen our understanding of the overall motor function system, contributing to a healthier society and medical care.
Speakers