Concurrent Session 10: Molecular Drivers of OA

Moderators: Raghu Yammani & Ingrid Meulenbelt

Phagocyte-Induced Fibroblast Gene Activation: Novel Insights in Regenerative Medicine
Thomas Lozito   

• Specific phagocyte populations are associated with tissue regeneration versus fibrosis
• Supplementing regeneration-associated phagocyte populations stimulate cartilage formation.
• Regenerative phagocyte populations modulate GP130 signaling to suppress fibrosis. 

Abstract Presentations:

68 EXAMINING THE ROLE OF SIRT1 CLEAVAGE ON AGE-DEPENDENT OA PROGRESSION FOR MALE MICE          
Mona Dvir-Ginzberg

69 INTRA-ARTICULAR ADMINISTRATION OF AGRIN INDUCES RAPID AND SUSTAINED PAIN RELIEF IN OSTEOARTHRITIS          
Suzanne Eldridge

70 LOSS OF MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE CHAPERONIN AGGRAVATES CHONDROCYTE CATABOLISM AND OSTEOARTHRITIC DEGENERATION       
Yu Shan Chen 

71 IDENTIFICATION AND CHARACTERIZATION OF MIR-126-3P AS A DIAGNOSTIC BIOMARKER, MECHANISTIC DRIVER, AND THERAPEUTIC TARGET FOR KNEE OSTEOARTHRITIS  
Thomas G. Wilson

72 MANGANESE DIOXIDE NANOZYMES AS AN ROS SCAVENGING THERAPY FOR OSTEOARTHRITIS                                                              
Jessica Aldrich